I-Intermediates ye-Remazolam Benzenesulfonate (i-CAS No. 308242-23-1)
Izithethantonye:(3S)-(7-BroMo-2-oxo-5-pyridin-2-yl-2, 3-dihydro-1H-benzo [e] [1,4]diazepin-3-yl) -propionic acid Methylester; Methyl3-[(3S)-7-bromo-2-oxo-5-(2-pyridinyl)-2, 3-dihydro-1H-1, 4-benzodiazepin-3-yl]propanoate; (S)-Methyl3-(7-bromo-2-oxo-5-(pyridin-2-yl)-2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanoate; 3-[(S) -7-bromo-2-oxo-5-pyridin-2-yl-2, 3-dihydro-1H-1, 4-benzodiazepin-3-yl] -propionicacidmethylester.
Inombolo yeCAS:308242-23-1
Ifomula yemolekyuli:C18H16BrN3O3
Ubunzima beMolekyuli:402.24
Isicelo: Amachiza, abaphakathi, i-APIs, i-custom synthesis, iikhemikhali
Usebenzisa:Abaphakathi beRemazolam Benzenesulfonate
Ulwakhiwo
Ukongama:Umthengisi ogqwesileyo, uMgangatho oPhezulu, iXabiso loKhuphiswano, ukuhanjiswa ngokukhawuleza, ukuPhendula ngokukhawuleza
Iindidi ezinxulumeneyo:Imichiza emihle
| Indawo yokubilisa | 545.3±50.0 °C(Kuqikelelwe) |
| Ukuxinana | 1.52±0.1 g/cm3(Kuxelwe kwangaphambili) |
| Imeko yokugcina | Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi |
| pKa | 11.15±0.70(Kuqikelelwe) |
| Iinkcukacha ezikhethekileyo ngokweemfuno zabathengi | |
| Imbonakalo | Umgubo omhlophe ukuya kumthubi |
| Amanzi | 1.0% ubukhulu |
| Isomer | 1.5% ubuninzi |
| Ubunyulu | 98.0％min |
Imiqathango yokuphatha ngokukhuselekileyo:
Ukuphatha kwindawo engena umoya. Nxiba iimpahla ezifanelekileyo zokuzikhusela. Kuphephe ukudibana nolusu namehlo. Kuphephe ukubunjwa kothuli kunye ne-aerosols. Sebenzisa izixhobo ezingatshisiyo. Thintela umlilo obangelwa ngumphunga wokukhupha i-electrostatic.
Imiqathango yogcino olukhuselekileyo, kuquka nakuphi na ukungahambelani:
Gcina isikhongozeli sivalwe ngokuqinileyo kwindawo eyomileyo, epholileyo nengena umoya. Gcina ngaphandle kwizikhongozeli zokutya okanye izinto ezingahambelaniyo.
I-Jingye ineesethi ze-86 ze-reactors iyonke, apho ivolomu ye-enamel reactor yi-69, ukusuka kwi-50 ukuya kwi-3000L. Inani le-reactors ezingenasici li-18, ukusuka kwi-50 ukuya kwi-3000L. I-QC ixhotyiswe ngamakhulu azo zonke iintlobo zezixhobo zokuhlalutya. Iyakwazi ukuhlangabezana nemveliso yorhwebo kunye nohlalutyo olubanzi lwemveliso. Le mveliso yimveliso yendawo ephezulu kwaye inokuhanjiswa ngokweemfuno zabathengi.
I-Jiangsu Jingye Pharmaceutical Co., Ltd. yayifudula ibizwa ngokuba yi-Jintan Depei Chemical Co., Ltd. eyasekwa ngo-1994, kwaye iguqukela kumvelisi wamachiza ochwephesha ngo-2016. Emva kweminyaka engamashumi amabini yophuhliso, i-Jingye Pharmaceutical iye yakhula yaba yingcali kunye neyonyango ebanzi. Ishishini elidibanisa i-R&D, imveliso, ukungenisa elizweni kunye nokuthumela ngaphandle kunye neenkxaso ezimbini eziseShanghai naseLianyungang.