Kwinkalo yekhemikhali yamayeza, iikhompawundi ezimbalwa zigqame kwizicelo zazo ezahlukeneyo kunye nokusebenza njenge dibenzosuberone. Le khompawundi engaqhelekanga, ekwabizwa ngokuba yi-1011-dihydrodibenzo[a,d]cyclohepten-5-one, iye yatsala umdla kumandla ayo onyango kwiinkalo ezahlukeneyo zonyango. Masingene nzulu kwihlabathi le dibenzosuberone kwaye siphonononge iingenelo zalo ekubeni yinxalenye ebalulekileyo yokhathalelo lwempilo lwangoku.
Kwiphambili yophando lwezonyango, dibenzosuberone ubonisa iipropati ukuba kakhulu ukwandisa ixabiso layo. Iyaziwa ngokukwazi kwayo ukusebenza njenge-prodrug, oku kuthetha ukuba inokuguqulwa ibe yi-agent esebenzayo ye-pharmacological emzimbeni. Le propati iyingqayizivele yenza iziphumo zonyango ezilungiselelwe ngelixa unciphisa iziphumo ebezingalindelekanga, iyenza ibe lukhetho lokuqala lophuhliso lwamachiza.
Usetyenziso lwezonyango lwe dibenzocycloconone lubanzi kakhulu kwaye lunwenwela kwiinkalo ezininzi zamayeza. Eyona nto ibalulekileyo kwezi yindima yayo ekunyangeni ukuphazamiseka kwemithambo-luvo. Uphando lubonisa ukuba dibenzosuberone inokunceda ukukhulula iimpawu ezinxulumene neemeko ezifana nesifo sikaParkinson, kwaye inokunceda kulawulo lwe-dopamine. Ukongeza, iipropathi zayo ezinokuthi zithintele ukuxhuzula ziye zaphononongwa, zicebisa ukuba zisetyenziswe kunyango lokuxhuzula.
Ngaphezu koko, iziphumo ezichasayo ze- dibenzosuberone ziye zafundwa ngokubanzi, zivula ithuba lokusetyenziswa kwayo kunyango lwezifo ezivuthayo. Ukusuka kwi-arthritis ukuya kwizifo ezizimelayo, le khompawundi ukukwazi ukulungelelanisa iimpendulo zokuzivikela komzimba kunokukhokelela kwinkqubela phambili enkulu yonyango.
Ukongeza koku, dibenzosuberone nayo inokusebenzisa kwi-endocrinology. Ukukwazi kwayo ukusebenzisana nenkqubo ye-hormonal yomzimba ibonisa ukuba idlala indima ekulawuleni iinkqubo ezifana ne-metabolism kunye ne-homeostasis yamandla. Olu luhlu lubanzi lwemisebenzi lubonisa ukuguquguquka kunye nokubaluleka kwe dibenzosuberone kwichemistry yamayeza yangoku.
Iinzuzo ze dibenzocycloconone zandisa ngaphaya kwemiphumo yayo yonyango. Ubume bayo beekhemikhali buguqulwa ngokulula, buvumela abaphandi ukuba baphuhlise i-derivatives kunye nokusebenza okuphuculweyo okanye iziphumo ezijoliswe kuzo. Oku kubhetyebhetye kuyilo kunye nokusetyenziswa kwenza kube sisixhobo esixabisekileyo sokufumana iziyobisi kunye nophuhliso.
Kwabo bafuna i dibenzocycloheptone ekumgangatho ophezulu, iJingye Pharmaceutical ibonelela ngezisombululo ezithembekileyo. Iwebhusayithi yabo kuhttps://www.jingyepharma.com/dibenzosuberone-1011-dihydrodibenzoadcyclohepten-5-one-product/ibonelela ngolwazi olubanzi malunga nalo mdibaniso uneenkalo ezininzi. I-Jingye Pharmaceuticals izimisele ukugqwesa kwaye inembali yokuvelisa amayeza akumgangatho ophezulu, eqinisekisa ukuba unofikelelo olulula noluthembekileyo kwi dibenzocycloheptanone.
Isishwankathelo, i- dibenzosuberone ibonisa ukuqhubela phambili okutsha kwisayensi yezamayeza. Uluhlu olubanzi lwezicelo, ukusuka kwi-neurology ukuya kwi-endocrinology, kunye namandla ayo okwenziwa ngokwezifiso ayenze ilitye lembombo kunyango lwangoku. Njengoko siqhubeka nokuphonononga ubunzulu beli khompawundi imangalisayo, izibonelelo ze dibenzosuberone ngokungathandabuzekiyo ziya kubumba ikamva eliqaqambileyo kukhathalelo lwempilo.
NdwendwelaJingyeAmachiza namhlanje ukufunda ngakumbi malunga nenkqubela phambili eyenziwe kwi dibenzosuberone kwaye ufunde ukuba le khompawundi inokutshintsha njani inguqu ekuqondeni kwakho ukusungula amayeza.
Ixesha lokuposa: Mar-29-2024