Usetyenziso lwezoNyango lweDibenzosuberone

I-Dibenzosuberone, i-polycyclic enuka i-hydrocarbon, ifumene ingqwalasela ebalulekileyo kuluntu lwezenzululwazi ngenxa yemisebenzi yayo yebhayoloji ethembisayo. Ngelixa isaziwa ngokuyintloko ngendima yayo njengendawo ephakathi kwi-organic synthesis, dibenzosuberone kunye nezinto eziphuma kuyo ziye zabonisa ukubanakho kwezicelo zonyango ezahlukeneyo. Kweli nqaku, siza kuphonononga iingenelo ezinokwenzeka kunye nokusetyenziswa kwe dibenzosuberone kwicandelo lezonyango.

Izicelo zonyango ezinokubakho

Iinkcazelo ngeempawu ezichasene nomhlaza:

Izifundo ezininzi zibonise ukuba i-dibenzosuberone kunye nezinto eziphuma kuyo zibonisa iipropati ezichasene nomhlaza. Ezi khompawundi ziye zaboniswa ukuba ziphembelele i-apoptosis (ukufa kweseli ecwangcisiweyo) kwiiseli zomhlaza, inqanda ukukhula kwethumba, kwaye ithintele imetastasis.

Iinkqubo eziphantsi kwezi ziphumo zinzima kwaye zihlala zibandakanya ukusebenzisana kunye neendlela zokubonisa iselula.

Iimpembelelo zeNeuroprotective:

I-Dibenzosuberone ibonise iziphumo ze-neuroprotective kwizifundo zangaphambili. Kuye kwaboniswa ukunciphisa uxinzelelo lwe-oxidative, ukuvuvukala, kunye nomonakalo we-neuronal obangelwa zizifo ezahlukeneyo ze-neurological.

Le khompawundi inokubonelela ngezibonelelo zonyango ezinokubakho kwiimeko ezifana nesifo sika-Alzheimer, isifo sikaParkinson, kunye nesifo sohlangothi.

Umsebenzi wokuchasana nokudumba:

I-Dibenzosuberone ibonise iipropati ezichasayo, okwenza ukuba ibe ngumviwa onokuthi ufumane unyango lwezifo ezivuthayo. Inokunceda ukunciphisa ukuvuvukala ngokuthintela ukuveliswa kwe-cytokines e-pro-inflammatory.

Umsebenzi weAntimicrobial:

Ezinye izinto eziphuma kwi-dibenzosuberone zibonise umsebenzi we-antimicrobial ngokuchasene noluhlu lweebhaktheriya kunye nomngundo. Le propati inokubenza babe luncedo ekuphuhlisweni kwamachiza amatsha kunye ne-antifungal agents.

IiNdlela zokuSebenza

Iindlela ezichanekileyo apho i-dibenzosuberone zenza iziphumo zayo zebhayoloji aziqondwa ngokupheleleyo kodwa kucingelwa ukuba zibandakanya intsebenziswano kunye neethagethi ezahlukeneyo zeselula, kubandakanya:

I-Receptors: I-Dibenzosuberone inokubophelela kwaye isebenze okanye inqanda i-receptors ethile, ekhokelela kwiziganeko ezisezantsi zomqondiso.

I-Enzymes: Le khompawundi inokuthintela okanye isebenze ii-enzymes ezithile ezibandakanyekayo kwiinkqubo zeselula ezifana nokwanda kweeseli, i-apoptosis, kunye nokudumba.

Uxinzelelo lwe-oxidative: I-Dibenzosuberone inokusebenza njenge-antioxidant, ikhusela iiseli kumonakalo obangelwa yi-oxygen esebenzayo.

Imingeni kunye nezikhokelo zexesha elizayo

Ngelixa izicelo ezinokwenzeka zonyango ze dibenzosuberone zithembisa, kukho imingeni emininzi ekufuneka iqwalaselwe phambi kokuba isetyenziswe njengearhente yonyango. Ezi ziquka:

Ubuthi: Ubutyhefu be dibenzosuberone kunye nezinto eziphuma kuyo kufuneka zihlolwe ngononophelo ukuze kuqinisekiswe ukhuseleko lwazo ekusetyenzisweni kwabantu.

I-Bioavailability: Ukuphucula ukufumaneka kwe-dibenzosuberone kubalulekile kunikezelo lwayo olusebenzayo kwiithishu ekujoliswe kuzo.

Ukuqulunqwa kweziyobisi: Ukuphuhlisa ukuqulunqwa kweziyobisi ezifanelekileyo zokunikezelwa kwe dibenzosuberone ngumsebenzi onzima.

Ukuqukumbela

I-Dibenzosuberone kunye ne-derivatives yayo imele indawo ethembisayo yophando kunye nezicelo ezinokubakho kunyango lwezifo ezahlukeneyo. Uphononongo olongezelelweyo luyafuneka ukuze kuqondwe ngokupheleleyo iindlela zokusebenza kwezi khompawundi kunye nokuphuhlisa ii-arhente zonyango ezikhuselekileyo nezisebenzayo.